SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03722

Signal sequence   MVGQMYCYPGSHLARALTRALALALVLALLVGPFLSGLAGA

Length  41

Organism  Homo sapiens (Human)

UniProt ID  Q8NHP8,

Motif  1..41



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03722.cif

Structure  SPKB03722.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4187.09124

Aliphatic index  135.8536585

Isoelectric point  9.326158392

Charge (pH=7)   2.025211223

Topological polar surface area  1506.46

Aromaticity  0.073170732

Average rotatable bonds  3.195121951

Number of hydrogen bond donors  54

Number of hydrogen bond acceptors  54

X logP energy  -9.75356

Hydropathy 



Literature Information


Title  Biochemical characterization and lysosomal localization of the mannose-6-phosphate protein p76 (hypothetical protein LOC196463).

DOI  10.1042/BJ20061205,

Publication Year  2007

PubMed ID  17105447,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.