SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03719

Signal sequence   MGTVSSRRSWWPLPLLLLLLLLLGPAGARA

Length  30

Organism  Homo sapiens (Human)

UniProt ID  Q8NBP7,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  2P4E,

Predicted Structure ID  SPKB03719.cif

Structure  SPKB03719.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3259.00524

Aliphatic index  149.6666667

Isoelectric point  12.801071

Charge (pH=7)   2.997974365

Topological polar surface area  1179.05

Aromaticity  0.066666667

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  43

Number of hydrogen bond acceptors  39

X logP energy  -5.60439

Hydropathy 



Literature Information


Title  The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.

DOI  10.1073/pnas.0335507100,

Publication Year  2003

PubMed ID  12552133,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.