SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03709

Signal sequence   MGIGRSEGGRRGAALGVLLALGAALLAVGSA

Length  31

Organism  Homo sapiens (Human)

UniProt ID  Q8N474,

Motif  1..31



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03709.cif

Structure  SPKB03709.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2865.39004

Aliphatic index  129.3548387

Isoelectric point  12.19913393

Charge (pH=7)   1.999749488

Topological polar surface area  1199.78

Aromaticity  0

Average rotatable bonds  3.129032258

Number of hydrogen bond donors  44

Number of hydrogen bond acceptors  39

X logP energy  -13.84019

Hydropathy 



Literature Information


Title  Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules.

DOI  10.1074/jbc.M108533200,

Publication Year  2002

PubMed ID  11741940,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.