SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03704

Signal sequence   MFRKFVIMLVLSLLVAAGISQA

Length  22

Organism  Tyria jacobaeae (Cinnabar moth)

UniProt ID  Q8MP06,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03704.cif

Structure  SPKB03704.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2408.04484

Aliphatic index  159.5454545

Isoelectric point  11.65177567

Charge (pH=7)   1.997685954

Topological polar surface area  845.89

Aromaticity  0.090909091

Average rotatable bonds  3.681818182

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  30

X logP energy  -2.85123

Hydropathy 



Literature Information


Title  Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae.

DOI  10.1073/pnas.082674499,

Publication Year  2002

PubMed ID  11972041,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.