SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03703

Signal sequence   MKTQFAILLVALVLFQMFAQSDA

Length  23

Organism  Opisthacanthus madagascariensis (Scorpion)

UniProt ID  Q8MMJ7,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03703.cif

Structure  SPKB03703.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2586.14574

Aliphatic index  127.3913043

Isoelectric point  6.337367167

Charge (pH=7)   -0.00186425

Topological polar surface area  936.57

Aromaticity  0.130434783

Average rotatable bonds  3.739130435

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  33

X logP energy  -4.3064

Hydropathy 



Literature Information


Title  IsCT, a novel cytotoxic linear peptide from scorpion Opisthacanthus madagascariensis.

DOI  10.1006/bbrc.2001.5472,

Publication Year  2001

PubMed ID  11520071,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.