SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03691

Signal sequence   MKPLLETLYLLGMLVPGGLG

Length  20

Organism  Homo sapiens (Human)

UniProt ID  Q8IVL8,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03691.cif

Structure  SPKB03691.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2115.66054

Aliphatic index  151

Isoelectric point  6.402001171

Charge (pH=7)   -0.001386026

Topological polar surface area  702.42

Aromaticity  0.05

Average rotatable bonds  3.4

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  27

X logP energy  -1.0447

Hydropathy 



Literature Information


Title  Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity.

DOI  10.1074/jbc.M111.265819,

Publication Year  2011

PubMed ID  21921028,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.