General Information
SPKB ID SPKB03690
Signal sequence MACLGFLLPVGFLLLISTVAG
Length 21
Organism Homo sapiens (Human)
UniProt ID Q8IUH8,
Motif 1..21
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB03690.cif
Physicochemical Information
Molecular weight 2135.69414
Aliphatic index 167.1428571
Isoelectric point 5.922539791
Charge (pH=7) -0.063990417
Topological polar surface area 676.99
Aromaticity 0.095238095
Average rotatable bonds 3.142857143
Number of hydrogen bond donors 24
Number of hydrogen bond acceptors 26
X logP energy -1.2894
Hydropathy 
Literature Information
Title Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.
Publication Year 2004
PubMed ID 15385547,
Patent ID NA,
