SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03662

Signal sequence   MIVLLLLISYCFA

Length  13

Organism  Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)

UniProt ID  Q86M34,

Motif  1..13



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03662.cif

Structure  SPKB03662.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1498.94524

Aliphatic index  210

Isoelectric point  5.919503212

Charge (pH=7)   -0.064840831

Topological polar surface area  452.98

Aromaticity  0.153846154

Average rotatable bonds  3.615384615

Number of hydrogen bond donors  17

Number of hydrogen bond acceptors  18

X logP energy  2.0346

Hydropathy 



Literature Information


Title  The beta-N-acetylhexosaminidase of Entamoeba histolytica is composed of two homologous chains and has been localized to cytoplasmic granules.

DOI  10.1016/j.molbiopara.2004.09.003,

Publication Year  2004

PubMed ID  15555733,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.