SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03647

Signal sequence   MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAG

Length  43

Organism  Homo sapiens (Human)

UniProt ID  Q7Z5A7,

Motif  1..43



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03647.cif

Structure  SPKB03647.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4521.26204

Aliphatic index  82.09302326

Isoelectric point  8.527144765

Charge (pH=7)   0.935599031

Topological polar surface area  1744.75

Aromaticity  0.093023256

Average rotatable bonds  3.255813953

Number of hydrogen bond donors  63

Number of hydrogen bond acceptors  64

X logP energy  -19.00926

Hydropathy 



Literature Information


Title  Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.

DOI  10.1161/CIRCULATIONAHA.117.032398,

Publication Year  2018

PubMed ID  29453251,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.