SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03610

Signal sequence   MGLGLRGWGRPLLTVATALMLPVKPPAGSWG

Length  31

Organism  Homo sapiens (Human)

UniProt ID  Q6UWY2,

Motif  1..31



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03610.cif

Structure  SPKB03610.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3203.90054

Aliphatic index  103.8709677

Isoelectric point  12.51647815

Charge (pH=7)   2.997682643

Topological polar surface area  1143.25

Aromaticity  0.064516129

Average rotatable bonds  3.096774194

Number of hydrogen bond donors  40

Number of hydrogen bond acceptors  40

X logP energy  -7.23256

Hydropathy 



Literature Information


Title  NSP4, an elastase-related protease in human neutrophils with arginine specificity.

DOI  10.1073/pnas.1200470109,

Publication Year  2012

PubMed ID  22474388,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.