SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03585

Signal sequence   MKFQGPLACLLLALCLGSGEA

Length  21

Organism  Homo sapiens (Human)

UniProt ID  Q6E0U4,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03585.cif

Structure  SPKB03585.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2135.62574

Aliphatic index  125.7142857

Isoelectric point  6.13535235

Charge (pH=7)   -0.124485044

Topological polar surface area  763.17

Aromaticity  0.047619048

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  29

X logP energy  -5.062

Hydropathy 



Literature Information


Title  Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.

DOI  10.1016/j.ygeno.2004.03.010,

Publication Year  2004

PubMed ID  15234001,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.