SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03574

Signal sequence   MGTALVQHGGCCLLCLSLLLLGCWAELGSG

Length  30

Organism  Rattus norvegicus (Rat)

UniProt ID  Q63372,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03574.cif

Structure  SPKB03574.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3019.66124

Aliphatic index  133.3333333

Isoelectric point  5.353948823

Charge (pH=7)   -1.157230351

Topological polar surface area  1092.77

Aromaticity  0.033333333

Average rotatable bonds  3.266666667

Number of hydrogen bond donors  42

Number of hydrogen bond acceptors  42

X logP energy  -8.9856

Hydropathy 



Literature Information


Title  Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.

DOI  10.1074/jbc.273.52.34716,

Publication Year  1998

PubMed ID  9856994,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.