SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03548

Signal sequence   MAAASAGATRLLLLLLMAVAAPSRA

Length  25

Organism  Homo sapiens (Human)

UniProt ID  Q5UCC4,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6WW7,

Predicted Structure ID  SPKB03548.cif

Structure  SPKB03548.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2440.00374

Aliphatic index  141.2

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  937.42

Aromaticity  0

Average rotatable bonds  3.12

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  33

X logP energy  -8.31906

Hydropathy 



Literature Information


Title  Structural basis for membrane insertion by the human ER membrane protein complex.

DOI  10.1126/science.abb5008,

Publication Year  2020

PubMed ID  32439656,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.