SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03524

Signal sequence   MIFTNAILVISALLPATVLS

Length  20

Organism  Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)

UniProt ID  Q4WL81,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6YGE,

Predicted Structure ID  SPKB03524.cif

Structure  SPKB03524.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2087.58894

Aliphatic index  180.5

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  731.44

Aromaticity  0.05

Average rotatable bonds  3.25

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  27

X logP energy  -3.5725

Hydropathy 



Literature Information


Title  Discovery of fungal surface NADases predominantly present in pathogenic species.

DOI  10.1038/s41467-021-21307-z,

Publication Year  2021

PubMed ID  33712585,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.