SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03500

Signal sequence   MVCLKLPGGSYMAKLTVTLMVLSSPLALA

Length  29

Organism  Homo sapiens (Human)

UniProt ID  Q30154,

Motif  1..29



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03500.cif

Structure  SPKB03500.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3008.78804

Aliphatic index  134.4827586

Isoelectric point  9.405774727

Charge (pH=7)   1.934569102

Topological polar surface area  1033.96

Aromaticity  0.034482759

Average rotatable bonds  3.344827586

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  42

X logP energy  -6.2678

Hydropathy 



Literature Information


Title  Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1).

DOI  10.1515/bchm2.1983.364.1.749,

Publication Year  1983

PubMed ID  6576979,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.