SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03491

Signal sequence   MRTLWIMAVLLVGVEG

Length  16

Organism  Bothrops erythromelas (Caatinga lance head)

UniProt ID  Q2HZ28,

Motif  1..16



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03491.cif

Structure  SPKB03491.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1788.23974

Aliphatic index  158.125

Isoelectric point  6.410149741

Charge (pH=7)   -0.000243889

Topological polar surface area  635.04

Aromaticity  0.0625

Average rotatable bonds  3.625

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  22

X logP energy  -1.15553

Hydropathy 



Literature Information


Title  BE-I-PLA2, a novel acidic phospholipase A2 from Bothrops erythromelas venom: isolation, cloning and characterization as potent anti-platelet and inductor of prostaglandin I2 release by endothelial cells.

DOI  10.1016/j.bcp.2006.04.032,

Publication Year  2006

PubMed ID  16750518,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.