SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03456

Signal sequence   MTSIFHFAIIFMLILQIRIQLSEE

Length  24

Organism  Homo sapiens (Human)

UniProt ID  Q15399,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6NIH,

Predicted Structure ID  SPKB03456.cif

Structure  SPKB03456.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2894.52614

Aliphatic index  150.4166667

Isoelectric point  5.493087469

Charge (pH=7)   -0.907559676

Topological polar surface area  1044.67

Aromaticity  0.125

Average rotatable bonds  4.083333333

Number of hydrogen bond donors  36

Number of hydrogen bond acceptors  36

X logP energy  -2.92713

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.