SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03453

Signal sequence   MKPPRPVRTCSKVLVLLSLLAIHQTTTA

Length  28

Organism  Homo sapiens (Human)

UniProt ID  Q14624,

Motif  1..28



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  9C4F,

Predicted Structure ID  SPKB03453.cif

Structure  SPKB03453.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3074.78034

Aliphatic index  121.7857143

Isoelectric point  11.65160089

Charge (pH=7)   4.026321984

Topological polar surface area  1191.64

Aromaticity  0

Average rotatable bonds  3.5

Number of hydrogen bond donors  43

Number of hydrogen bond acceptors  43

X logP energy  -10.50256

Hydropathy 



Literature Information


Title  Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma.

DOI  10.1093/jb/117.2.400,

Publication Year  1995

PubMed ID  7541790,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.