SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03449

Signal sequence   MEGDRVAGRPVLSSLPVLLLLPLLMLRAAA

Length  30

Organism  Homo sapiens (Human)

UniProt ID  Q14112,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03449.cif

Structure  SPKB03449.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3172.92494

Aliphatic index  159.3333333

Isoelectric point  10.30863985

Charge (pH=7)   1.000195972

Topological polar surface area  1181.61

Aromaticity  0

Average rotatable bonds  3.4

Number of hydrogen bond donors  41

Number of hydrogen bond acceptors  40

X logP energy  -6.67849

Hydropathy 



Literature Information


Title  Nidogen-2: a new basement membrane protein with diverse binding properties.

DOI  10.1006/jmbi.1998.2004,

Publication Year  1998

PubMed ID  9733643,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.