SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03444

Signal sequence   MMAAGAALALALWLLMPPVEVGG

Length  23

Organism  Homo sapiens (Human)

UniProt ID  Q13445,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03444.cif

Structure  SPKB03444.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2282.84584

Aliphatic index  136.0869565

Isoelectric point  3.849983241

Charge (pH=7)   -1.000240578

Topological polar surface area  739.03

Aromaticity  0.043478261

Average rotatable bonds  3

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  28

X logP energy  -1.5195

Hydropathy 



Literature Information


Title  Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

DOI  10.1073/pnas.0908958106,

Publication Year  2009

PubMed ID  19892738,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.