SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03436

Signal sequence   MTTRKTASSLQLLGKITGTKAGTKQKKMNFINGLIWLYMCVWMVHG

Length  46

Organism  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

UniProt ID  Q12396,

Motif  1..46



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03436.cif

Structure  SPKB03436.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  5187.29014

Aliphatic index  84.7826087

Isoelectric point  11.11842132

Charge (pH=7)   7.024294746

Topological polar surface area  2005.53

Aromaticity  0.086956522

Average rotatable bonds  3.869565217

Number of hydrogen bond donors  73

Number of hydrogen bond acceptors  73

X logP energy  -16.77263

Hydropathy 



Literature Information


Title  Emp47p and its close homolog Emp46p have a tyrosine-containing endoplasmic reticulum exit signal and function in glycoprotein secretion in Saccharomyces cerevisiae.

DOI  10.1091/mbc.e02-01-0027,

Publication Year  2002

PubMed ID  12134087,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.