SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03404

Signal sequence   MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQP

Length  35

Organism  Homo sapiens (Human)

UniProt ID  Q04756,

Motif  1..35



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03404.cif

Structure  SPKB03404.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3949.89054

Aliphatic index  133.7142857

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  1216.89

Aromaticity  0.142857143

Average rotatable bonds  3.114285714

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  41

X logP energy  1.83454

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.