SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03339

Signal sequence   MRIHYLLFALLFLFLVPVPGHG

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P81534,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03339.cif

Structure  SPKB03339.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2554.18034

Aliphatic index  155

Isoelectric point  9.353535051

Charge (pH=7)   1.178948756

Topological polar surface area  796.33

Aromaticity  0.181818182

Average rotatable bonds  3.454545455

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  28

X logP energy  2.13327

Hydropathy 



Literature Information


Title  Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic.

DOI  10.1074/jbc.M008557200,

Publication Year  2001

PubMed ID  11085990,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.