SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03322

Signal sequence   MKVSTAFLCLLLTVSAFSAQVLA

Length  23

Organism  Cavia porcellus (Guinea pig)

UniProt ID  P80325,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03322.cif

Structure  SPKB03322.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2413.95944

Aliphatic index  140

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  873.78

Aromaticity  0.086956522

Average rotatable bonds  3.391304348

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  33

X logP energy  -6.3567

Hydropathy 



Literature Information


Title  Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.

DOI  10.1084/jem.179.3.881,

Publication Year  1994

PubMed ID  7509365,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.