SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03307

Signal sequence   MCCTKSLLLAALMSVLLLHLCGESEA

Length  26

Organism  Homo sapiens (Human)

UniProt ID  P78556,

Motif  1..26



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03307.cif

Structure  SPKB03307.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2750.39884

Aliphatic index  142.6923077

Isoelectric point  5.485653311

Charge (pH=7)   -1.093775546

Topological polar surface area  1001.04

Aromaticity  0

Average rotatable bonds  3.576923077

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  40

X logP energy  -7.2881

Hydropathy 



Literature Information


Title  Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2.

DOI  10.1074/jbc.272.9.5846,

Publication Year  1997

PubMed ID  9038201,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.