General Information
SPKB ID SPKB03281
Signal sequence MRFLAATFLLLALSTAAQA
Length 19
Organism Homo sapiens (Human)
UniProt ID P61916,
Motif 1..19
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB03281.cif
Physicochemical Information
Molecular weight 2009.43744
Aliphatic index 134.2105263
Isoelectric point 10.55000222
Charge (pH=7) 0.997980988
Topological polar surface area 752.8
Aromaticity 0.105263158
Average rotatable bonds 3.368421053
Number of hydrogen bond donors 27
Number of hydrogen bond acceptors 26
X logP energy -5.00423
Hydropathy 
Literature Information
Title Identification of HE1 as the second gene of Niemann-Pick C disease.
DOI 10.1126/science.290.5500.2298,
Publication Year 2000
PubMed ID 11125141,
Patent ID NA,
