SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03271

Signal sequence   MYRMQLLSCIALSLALVTNS

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P60568,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6LX3,

Predicted Structure ID  SPKB03271.cif

Structure  SPKB03271.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2227.72354

Aliphatic index  141.5

Isoelectric point  8.527213491

Charge (pH=7)   0.935155858

Topological polar surface area  865.45

Aromaticity  0.05

Average rotatable bonds  3.7

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  32

X logP energy  -7.27193

Hydropathy 



Literature Information


Title  Amino acid sequence and post-translational modification of human interleukin 2.

DOI  10.1073/pnas.81.20.6486,

Publication Year  1984

PubMed ID  6333684,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.