SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03267

Signal sequence   MLSCRLQCALAALCIVLALGGVTG

Length  24

Organism  Rattus norvegicus (Rat)

UniProt ID  P60042,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03267.cif

Structure  SPKB03267.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2376.97764

Aliphatic index  154.5833333

Isoelectric point  8.04679067

Charge (pH=7)   0.81205684

Topological polar surface area  878.07

Aromaticity  0

Average rotatable bonds  3.25

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  33

X logP energy  -7.39843

Hydropathy 



Literature Information


Title  A new prosomatostatin-derived peptide reveals a pattern for prohormone cleavage at monobasic sites.

DOI  10.1126/science.2891188,

Publication Year  1987

PubMed ID  2891188,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.