SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03248

Signal sequence   MASRWAVQLLLVAAWSMGCGEA

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P55000,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03248.cif

Structure  SPKB03248.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2350.79694

Aliphatic index  102.2727273

Isoelectric point  6.232433001

Charge (pH=7)   -0.062218605

Topological polar surface area  888.75

Aromaticity  0.090909091

Average rotatable bonds  3.363636364

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  31

X logP energy  -6.34613

Hydropathy 



Literature Information


Title  Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily.

DOI  10.1110/ps.8.4.810,

Publication Year  1999

PubMed ID  10211827,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.