SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03245

Signal sequence   MAEWLLSASWQRRAKAMTAAAGSAGRAAVPLLLCALLAPGGA

Length  42

Organism  Homo sapiens (Human)

UniProt ID  P54803,

Motif  1..42



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03245.cif

Structure  SPKB03245.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4210.00194

Aliphatic index  102.8571429

Isoelectric point  11.37963928

Charge (pH=7)   2.937479738

Topological polar surface area  1643.45

Aromaticity  0.047619048

Average rotatable bonds  3.166666667

Number of hydrogen bond donors  60

Number of hydrogen bond acceptors  56

X logP energy  -15.65869

Hydropathy 



Literature Information


Title  Cloning and expression of cDNA encoding human galactocerebrosidase, the enzyme deficient in globoid cell leukodystrophy.

DOI  10.1093/hmg/2.11.1841,

Publication Year  1993

PubMed ID  8281145,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.