SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03222

Signal sequence   MEPPDAPAQARGAPRLLLLAVLLAAHPDAQA

Length  31

Organism  Homo sapiens (Human)

UniProt ID  P50895,

Motif  1..31



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03222.cif

Structure  SPKB03222.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3174.71164

Aliphatic index  113.8709677

Isoelectric point  5.519371449

Charge (pH=7)   -0.908445141

Topological polar surface area  1242.93

Aromaticity  0

Average rotatable bonds  3.064516129

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  41

X logP energy  -10.19296

Hydropathy 



Literature Information


Title  The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver.

DOI  10.1073/pnas.92.12.5496,

Publication Year  1995

PubMed ID  7777537,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.