SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03221

Signal sequence   MKVSTAALAVLLCTMALWNEVFS

Length  23

Organism  Rattus norvegicus (Rat)

UniProt ID  P50229,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03221.cif

Structure  SPKB03221.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2499.03964

Aliphatic index  123.0434783

Isoelectric point  6.231833229

Charge (pH=7)   -0.062510328

Topological polar surface area  906.64

Aromaticity  0.086956522

Average rotatable bonds  3.47826087

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  34

X logP energy  -5.686

Hydropathy 



Literature Information


Title  Cytokine-induced neutrophil chemoattractant (CINC)-2 alpha, a novel member of rat GRO/CINCs, is a predominant chemokine produced by lipopolysaccharide-stimulated rat macrophages in culture.

DOI  10.1006/bbrc.1996.0511,

Publication Year  1996

PubMed ID  8607872,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.