SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03219

Signal sequence   MARSLLLPLQILLLSLALETAG

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P49862,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03219.cif

Structure  SPKB03219.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2336.90204

Aliphatic index  190.9090909

Isoelectric point  6.410149741

Charge (pH=7)   -0.000243889

Topological polar surface area  868.61

Aromaticity  0

Average rotatable bonds  3.545454545

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  30

X logP energy  -4.25053

Hydropathy 



Literature Information


Title  Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.

DOI  NA,

Publication Year  1994

PubMed ID  8034709,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.