SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03217

Signal sequence   MPVMRLFPCFLQLLAGLA

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P49763,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03217.cif

Structure  SPKB03217.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2020.58314

Aliphatic index  135.5555556

Isoelectric point  8.549912035

Charge (pH=7)   0.936006272

Topological polar surface area  645.43

Aromaticity  0.111111111

Average rotatable bonds  3.444444444

Number of hydrogen bond donors  22

Number of hydrogen bond acceptors  24

X logP energy  -0.33983

Hydropathy 



Literature Information


Title  Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

DOI  NA,

Publication Year  1994

PubMed ID  7929268,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.