SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03216

Signal sequence   MSGLSGPPARRGPFPLALLLLFLLGPRLVLA

Length  31

Organism  Homo sapiens (Human)

UniProt ID  P49755,

Motif  1..31



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03216.cif

Structure  SPKB03216.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3244.03404

Aliphatic index  144.8387097

Isoelectric point  12.801071

Charge (pH=7)   2.997974365

Topological polar surface area  1118.53

Aromaticity  0.064516129

Average rotatable bonds  3.161290323

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  38

X logP energy  -4.81149

Hydropathy 



Literature Information


Title  Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

DOI  10.1073/pnas.0908958106,

Publication Year  2009

PubMed ID  19892738,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.