SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03192

Signal sequence   MKILSVLLLALIICSIIDWSEG

Length  22

Organism  Leiurus hebraeus (Hebrew deathstalker scorpion) (Leiurus quinquestriatus hebraeus)

UniProt ID  P45628,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03192.cif

Structure  SPKB03192.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2431.02994

Aliphatic index  195

Isoelectric point  4.184374539

Charge (pH=7)   -1.062063843

Topological polar surface area  851.52

Aromaticity  0.045454545

Average rotatable bonds  3.727272727

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  31

X logP energy  -1.8003

Hydropathy 



Literature Information


Title  Analysis of the blocking activity of charybdotoxin homologs and iodinated derivatives against Ca2+-activated K+ channels.

DOI  10.1007/BF01870284,

Publication Year  1989

PubMed ID  2477548,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.