SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03183

Signal sequence   MRLLPRLLLLLLLVFPAT

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P43307,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03183.cif

Structure  SPKB03183.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2092.74394

Aliphatic index  216.6666667

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  684.47

Aromaticity  0.055555556

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  23

X logP energy  1.64624

Hydropathy 



Literature Information


Title  HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.

DOI  10.1038/356443a0,

Publication Year  1992

PubMed ID  1557127,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.