SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03181

Signal sequence   MSLLSSRAARVPGPSSSLCALLVLLLLLTQPGPIAS

Length  36

Organism  Homo sapiens (Human)

UniProt ID  P42830,

Motif  1..36



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03181.cif

Structure  SPKB03181.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3633.40924

Aliphatic index  146.3888889

Isoelectric point  10.52640717

Charge (pH=7)   1.936002961

Topological polar surface area  1375.39

Aromaticity  0

Average rotatable bonds  3.166666667

Number of hydrogen bond donors  49

Number of hydrogen bond acceptors  50

X logP energy  -13.64556

Hydropathy 



Literature Information


Title  Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.

DOI  10.1046/j.1432-1327.1999.00166.x,

Publication Year  1999

PubMed ID  10095777,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.