SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03176

Signal sequence   MRQVWFSWIVGLFLCFFNVSSA

Length  22

Organism  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

UniProt ID  P41543,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6C26,

Predicted Structure ID  SPKB03176.cif

Structure  SPKB03176.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2638.14274

Aliphatic index  97.27272727

Isoelectric point  8.549912035

Charge (pH=7)   0.936006272

Topological polar surface area  914.77

Aromaticity  0.272727273

Average rotatable bonds  3.636363636

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  31

X logP energy  -3.18053

Hydropathy 



Literature Information


Title  The alpha subunit of the Saccharomyces cerevisiae oligosaccharyltransferase complex is essential for vegetative growth of yeast and is homologous to mammalian ribophorin I.

DOI  10.1083/jcb.128.4.525,

Publication Year  1995

PubMed ID  7860628,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.