SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03173

Signal sequence   MATHHTLWMGLALLGVLGDLQA

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P41222,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  4ORR,

Predicted Structure ID  SPKB03173.cif

Structure  SPKB03173.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2348.80644

Aliphatic index  133.1818182

Isoelectric point  6.496504159

Charge (pH=7)   -0.819751035

Topological polar surface area  868.42

Aromaticity  0.045454545

Average rotatable bonds  3.409090909

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -4.8708

Hydropathy 



Literature Information


Title  Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid.

DOI  10.1016/0006-8993(91)91666-o,

Publication Year  1991

PubMed ID  1726844,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.