SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03140

Signal sequence   MGVKASQTGFVVLVLLQCCSA

Length  21

Organism  Homo sapiens (Human)

UniProt ID  P36222,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8R41,

Predicted Structure ID  SPKB03140.cif

Structure  SPKB03140.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2154.62904

Aliphatic index  120.4761905

Isoelectric point  8.229691165

Charge (pH=7)   0.873739834

Topological polar surface area  818.21

Aromaticity  0.047619048

Average rotatable bonds  3.380952381

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -7.96

Hydropathy 



Literature Information


Title  Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period.

DOI  10.1042/bj2690265,

Publication Year  1990

PubMed ID  2375755,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.