SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03137

Signal sequence   MALRKGGLALALLLLSWVALGPRSLEG

Length  27

Organism  Homo sapiens (Human)

UniProt ID  P35858,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03137.cif

Structure  SPKB03137.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2806.44874

Aliphatic index  155.5555556

Isoelectric point  11.47969967

Charge (pH=7)   1.999457766

Topological polar surface area  1054.5

Aromaticity  0.037037037

Average rotatable bonds  3.444444444

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  35

X logP energy  -5.83256

Hydropathy 



Literature Information


Title  High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum.

DOI  NA,

Publication Year  1989

PubMed ID  2473065,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.