SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03134

Signal sequence   MRRGRLLEIALGFTVLLASYTSHG

Length  24

Organism  Homo sapiens (Human)

UniProt ID  P35555,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03134.cif

Structure  SPKB03134.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2662.14844

Aliphatic index  117.9166667

Isoelectric point  11.05370107

Charge (pH=7)   2.089808165

Topological polar surface area  1085.45

Aromaticity  0.083333333

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  41

Number of hydrogen bond acceptors  36

X logP energy  -9.27399

Hydropathy 



Literature Information


Title  Initial steps in assembly of microfibrils. Formation of disulfide-cross-linked multimers containing fibrillin-1.

DOI  10.1074/jbc.275.3.2205,

Publication Year  2000

PubMed ID  10636927,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.