SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03126

Signal sequence   MELRARGWWLLCAAAALVACTRG

Length  23

Organism  Rattus norvegicus (Rat)

UniProt ID  P35053,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03126.cif

Structure  SPKB03126.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2519.04174

Aliphatic index  106.5217391

Isoelectric point  8.834786621

Charge (pH=7)   1.875800056

Topological polar surface area  978.33

Aromaticity  0.086956522

Average rotatable bonds  3.434782609

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  32

X logP energy  -6.61739

Hydropathy 



Literature Information


Title  Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican.

DOI  10.1016/0006-291x(92)92398-h,

Publication Year  1992

PubMed ID  1417860,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.