SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03125

Signal sequence   MELRARGWWLLCAAAALVACARG

Length  23

Organism  Homo sapiens (Human)

UniProt ID  P35052,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03125.cif

Structure  SPKB03125.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2489.01544

Aliphatic index  110.8695652

Isoelectric point  8.834786621

Charge (pH=7)   1.875800056

Topological polar surface area  958.1

Aromaticity  0.086956522

Average rotatable bonds  3.391304348

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  31

X logP energy  -5.97829

Hydropathy 



Literature Information


Title  Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts.

DOI  10.1083/jcb.111.6.3165,

Publication Year  1990

PubMed ID  2148568,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.