SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03124

Signal sequence   MGGHPQLRLVKALLLLGLNPVSA

Length  23

Organism  Homo sapiens (Human)

UniProt ID  P34998,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03124.cif

Structure  SPKB03124.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2397.95094

Aliphatic index  152.6086957

Isoelectric point  11.65178972

Charge (pH=7)   2.088595045

Topological polar surface area  908.95

Aromaticity  0

Average rotatable bonds  3.391304348

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -6.11063

Hydropathy 



Literature Information


Title  Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor.

DOI  10.1074/jbc.M101838200,

Publication Year  2001

PubMed ID  11425856,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.