SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03116

Signal sequence   MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQ

Length  36

Organism  Escherichia coli (strain K12)

UniProt ID  P33937,

Motif  1..36



Activity Information


Pathway  Tat

Natural/Artificial  Natural

Subcellular location  Periplasmic space

Secretion efficiency  NA

Type  Tat/SPI



Structure Information


PDB ID  2PQ4,

Predicted Structure ID  SPKB03116.cif

Structure  SPKB03116.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3556.20854

Aliphatic index  92.5

Isoelectric point  12.81363632

Charge (pH=7)   4.997384298

Topological polar surface area  1500.73

Aromaticity  0.027777778

Average rotatable bonds  3.277777778

Number of hydrogen bond donors  53

Number of hydrogen bond acceptors  50

X logP energy  -18.46219

Hydropathy 



Literature Information


Title  The periplasmic nitrate reductase from Escherichia coli: a heterodimeric molybdoprotein with a double-arginine signal sequence and an unusual leader peptide cleavage site.

DOI  10.1111/j.1574-6968.1999.tb13564.x,

Publication Year  1999

PubMed ID  10234835,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.