SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03114

Signal sequence   MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSG

Length  34

Organism  Homo sapiens (Human)

UniProt ID  P33681,

Motif  1..34



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03114.cif

Structure  SPKB03114.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3754.36014

Aliphatic index  68.82352941

Isoelectric point  9.541616832

Charge (pH=7)   3.054700979

Topological polar surface area  1484.1

Aromaticity  0.117647059

Average rotatable bonds  3.5

Number of hydrogen bond donors  54

Number of hydrogen bond acceptors  53

X logP energy  -16.14546

Hydropathy 



Literature Information


Title  Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

DOI  10.1084/jem.174.3.625,

Publication Year  1991

PubMed ID  1714935,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.