SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03081

Signal sequence   MKPLLLAVSLGLIAALQA

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P31025,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03081.cif

Structure  SPKB03081.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1822.32304

Aliphatic index  190

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  638.57

Aromaticity  0

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  21

Number of hydrogen bond acceptors  23

X logP energy  -2.0243

Hydropathy 



Literature Information


Title  Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.

DOI  10.1021/acs.jproteome.5b00179,

Publication Year  2015

PubMed ID  25946035,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.