SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03063

Signal sequence   MCHQQLVISWFSLVFLASPLVA

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P29460,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  4GRW,

Predicted Structure ID  SPKB03063.cif

Structure  SPKB03063.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2490.01924

Aliphatic index  137.2727273

Isoelectric point  7.35902981

Charge (pH=7)   0.026918674

Topological polar surface area  856.97

Aromaticity  0.136363636

Average rotatable bonds  3.454545455

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -3.3104

Hydropathy 



Literature Information


Title  Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

DOI  10.1073/pnas.87.17.6808,

Publication Year  1990

PubMed ID  2204066,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.